Дабоцемаген аутофицел
Dabocemagene autoficelМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2365353-63-3
Химическое название
autologous human dermal fibroblast cells derived from skin biopsies, and transduced with a non-replicating, self-inactivating lentivirus vector that encodes human collagen type VII alpha 1 (COL7A1) under the control of a human cytomegalovirus (CMV) promoter / 5' UTR region with Kozak sequence; the constructis flanked by 5' and 3' long terminal repeats (LTR) and also contains a human immunodeficiency virus (HIV) Rev response element (RRE) and HIV central polypurine tract (cPPT) sequences. The vector is pseudotyped with the envelope glycoprotein (G) of vesicular stomatitis virus (VSV).
Cells isolated from the skin biopsies are expanded in standard growth medium containing serum. The cells are predominately fibroblasts (identified by CD90; ≥98%), with keratinocytes (identified by CD104) being the main residual cell type (≤2%).
Cells isolated from the skin biopsies are expanded in standard growth medium containing serum. The cells are predominately fibroblasts (identified by CD90; ≥98%), with keratinocytes (identified by CD104) being the main residual cell type (≤2%).
Иностранные названия
- Dabocemagenum autoficelum (латинское)
- Dabocemagene autoficel (английское)
- Dabocémagène autoficel (французское)
- Dabocemagén autoficel (испанское)
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