Дафсолимаб сетаритокс

Rec. INN (наименование, зарегистрированное ВОЗ)

2361013-28-5

immunoglobulin G2B-kappa, anti-[CD3E (CD3 epsilon, Leu-4)], Mus musculus monoclonal antibody conjugated to aglycosylated ricin toxin A (RTA);
gamma2b heavy chain Mus musculus (1-456) [VH (Mus musculus IGHV1-4*01 (95.9%) -(IGHD) -IGHJ4*01 (94.1%)) CDR-IMGT [8.8.13] (26-33.51-58.97-109) (1-120) -Mus musculus IGHG2B*02 (100%) (CH1 (121-217), hinge 1-22 (218-239), CH2 (240-349), CH3 (350-454), CHS (455-456)) (121-456)], (135-213’)-disulfide with kappa light chain Mus musculus (1’-213’) [V-KAPPA (Mus musculus IGKV4-59*01 (100%) -IGKJ5*01 (100%)) CDR-IMGT [5.3.9] (27-31.49-51.88-96) (1’-106’) -Mus musculus IGKC1*01 (100%) (107’-213’)];
dimer (229-229":232-232":235-235":238-238")-tetrakisdisulfide, glycoform alfa, produced in SP2/0-derived mouse myeloma cells, substituted at N⁶ of an average of 1.6 lysyl residues with 4-[(1RS)-1-{[l-methionyl-ricin toxin A-chain (Met-RTA, non-glycosylated, produced in Escherichia coli)-S²⁶⁰-yl]sulfanyl}ethyl]benzoyl groups

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