Далмитамиг

Prop. INN (наименование, предложенное ВОЗ)

2765077-69-6

immunoglobulin G4-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)] and anti-[Homo sapiens CD28 (T cell specific surface glycoprotein CD28, TP44)], Homo sapiens monoclonal antibody, bispecific, bivalent;
H-gamma4 heavy chain anti-EGFR Homo sapiens (1-447) [VH (Homo sapiens IGHV4-59*01 (92.8%) -(IGHD) -IGHJ3*01 (92.3%) M123>T (116), CDR-IMGT [8.7.15] (26-33.51-57.96-110)) (1-121) -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92, G4v7 CH2 delE1.4, P1.3, V1.2, A1.1 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 E1.4>del, F1.3>P (234), L1.2>V (235), G1.1>A (236), L92 (312) (232-340), CH3 (341-445), CHS (446-447)) (122-447)], (135-215')-disulfide with L-kappa light chain Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'-33'.51'-53'.90'-98')) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')];
H-gamma4 heavy chain anti-CD28 Homo sapiens (1''-448'') [VH (Homo sapiens IGHV4-59*01 (96.9%) -(IGHD) -IGHJ6*01 (100%), CDR-IMGT [8.7.16] (26''-33''.51''-57''.96''-111'')) (1''-122'') -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92, G4v7 CH2 delE1.4, P1.3, V1.2, A1.1, G4v8 CH3 R115, F116, P125 (CH1 (123''-220''), hinge 1-12 S10>P (230'') (221''-232''), CH2 E1.4>del, F1.3>P (235''), L1.2>V (236''), G1.1>A (237''), L92 (310'') (233''-341''), CH3 H115>R (436''), Y116>F (437''), L125>P (446'') (342''-446''), CHS (447’’-448'')) (123''-448'')], (136''-215''')-disulfide with L-kappa light chain Homo sapiens common (1'''-215''') [V-KAPPA (Homo sapiens IGKV3-20*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27'''-33'''.51'''-53'''.90'''-98''')) (1'''-108''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154'''), V101 (192''') (109'''-215''')]; dimer (227-228'':230-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

Поделиться этой страницей