Далутрафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2419918-89-9

humanized immunoglobulin G1-kappa anti-(human 5'- nucleotidase, ecto-5'-nucleotidase, CD73) variant (N²⁹⁷>A in the heavy chain) fused at the C-terminus of heavy chain (1-446), via peptidyl linker ⁴⁴⁷GGGGSGGGGSGGGGSGGGGSG⁴⁶⁷, to human transforming growth factor beta receptor type II (TGF-beta receptor type II, TGFβR2) extracellular domain (1-136, 468-603 in the current sequence), dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
humanized immunoglobulin G1-kappa, anti-[human 5'-nucleotidase (ecto-5'-nucleotidase, NT5E, EC:3.1.3.5, CD73)], fused at the C-terminus of both heavy chains via a peptide linker to the (1-136)-fragment of the extracellular domain of mature human TGF-beta receptor type 2 (TGFβR2, TGFBR2, transforming growth factor beta receptor type II, TGFβ type II receptor); gamma1 heavy chain (1-446) [Homo sapiens IGHV5-51*01; Homo sapiens IGHJ4*01; Homo sapiens IGHG1*03; VH: 1-117; CH1: 118- 215; hinge: 216-230; CH2: 231-340 (N297>A); CH3: 341-445; CHS: 446-446 (K447del); CDR Kabat H1: SSWIN (31-35); CDR Kabat H2: RIYPRAGDTNYAGKFKD (50-66); CDR Kabat H3: LLDYSMDY (99-106)] fused via a (G4S)4G linker (447-467) to the TGFβR2 (1-136)-peptide (468-603), (220-214')-disulfide with kappa light chain (1'-214') [Homo sapiens IGKV1-33*01; Homo sapiens IGKJ1*01; Homo sapiens IGKC*01; VL: 1-117; CL: 118-215; CDR Kabat L1: RASQDISNYLN (24-34); CDR Kabat L2: YTSRLHS (50-56); CDR Kabat L3: QQGNTLPLT (89-97)]; dimer (226-226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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