Данвилостомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2599198-80-6

immunoglobulin G1-kappa_scFv, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CD152)], each heavy chain being fused to a scFv anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279)], Homo sapiens and humanized monoclonal antibody, tetravalent, bispecific;
gamma1 heavy chain anti-CTLA4 Homo sapiens fused to scFv anti-PDCD1 humanized (1-701) [gamma1 heavy chain anti-CTLA4 Homo sapiens (1-447) [VH (Homo sapiens IGHV3-30*01 (94.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*01v, G1m17,1>G1m3,1, G1v14-1 CH2 A1.3, A1.2, A1, G1v20 CH2 A105 (CH1 K120>R (215) (119-216), hinge 1-15 (217-231), CH2 L1.3>A (235), L1.2>A (236), G1>A (238), K105>A (323) (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447)) (119-447)] -10-mer bis(tetraglycyl-seryl) linker (448-457) -scFv-VH-V-KAPPA anti-PDCD1 (458-701) [VH (Homo sapiens IGHV3-64*04 (76.5%) -(IGHD) -IGHJ4*01 (86.7%), CDR-IMGT [8.7.9] (483-490.508-514.553-561)) (458-572) -20-mer tetrakis(tetraglycyl-seryl) linker (573-592) -V-KAPPA (Homo sapiens IGKV1-27*01 (88.0%) -IGKJ4*01 (100%), CDR-IMGT [6.3.11] (619-624.642-644.681-691)) (593-701)], (221-215')-disulfide with kappa light chain anti-CTLA4 Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV3-20*01 (97.9%) -IGKJ1*01 (100%), CDR-IMGT [7.3.9] (27-33.51-53.90-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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