Дапиролизумаб пегол
Dapirolizumab pegolМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Drugbank
DB16131
CAS
1416147-64-2
Химическое название
immunoglobulin Fab' G1-kappa pegylated, anti-[Homo sapiens CD40LG (CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154)], pegylated humanized monoclonal antibody;
gamma1 heavy chain fragment VH-(CH1-hinge) (1-229) [humanized VH (Homo sapiens IGHV3-74*01 (76.50%) -(IGHD)-IGHJ1*01) [8.7.12] (1-118) -Homo sapiens IGHG1*01 (CH1 (119-216), hinge 1-11 (217-227)) (119-227) -dialanyl (228-229)], (221-214')-disulfide with kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1-NL1*01 (83.20%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01 (108'-214')]; conjugated via a linker of the maleimide group (thioether bond with cysteinyl h 11 (227)) to two linear chains of methoxy polyethylene glycol 20 (mPEG20).
gamma1 heavy chain fragment VH-(CH1-hinge) (1-229) [humanized VH (Homo sapiens IGHV3-74*01 (76.50%) -(IGHD)-IGHJ1*01) [8.7.12] (1-118) -Homo sapiens IGHG1*01 (CH1 (119-216), hinge 1-11 (217-227)) (119-227) -dialanyl (228-229)], (221-214')-disulfide with kappa light chain (1'-214') [humanized V-KAPPA (Homo sapiens IGKV1-NL1*01 (83.20%) -IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01 (108'-214')]; conjugated via a linker of the maleimide group (thioether bond with cysteinyl h 11 (227)) to two linear chains of methoxy polyethylene glycol 20 (mPEG20).
Структура
Иностранные названия
- Dapirolizumabum pegolum (латинское)
- Dapirolizumab pegol (английское)
- Dapirolizumab pegol (немецкое)
- Dapirolizumab pégol (французское)
- Dapirolizumab pegol (испанское)
Подробнее по теме
Узнайте дополнительные сведения о действующем веществе Дапиролизумаб пегол: