Давесомеран

Rec. INN (наименование, зарегистрированное ВОЗ)

2798905-80-1

messenger RNA (mRNA), 5'-capped, encoding a full-length, codon-optimised pre-fusion stabilised conformation variant (K981P and V982P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (Omicron variants B.1.1.529.4 and B.1.1.529.5; also known as BA.4 and BA.5; based upon GISAID No. EPI_ISL_12548717) further optimized by two additional stop codons, flanked by an artificial 5' untranslated region (UTR) and a 3' UTR derived from the human alpha globin gene (HBA1) modified to contain an identification and ratio (IDR) sequence to enable identification and relative ratio determination of individual RNA components in a multivalent mRNA vaccine, and terminated by a 3' poly(A) tail; contains N¹-methylpseudouridine instead of uridine (all-U>m¹Ψ).

Поделиться этой страницей