Давосетицепт

Rec. INN (наименование, зарегистрированное ВОЗ)

2307144-64-3

fragment (1-107) of human T-lymphocyte activation antigen CD80 (CTLA-4 (cytotoxic T-lymphocyte antigen 4) counterreceptor B7.1) variant (H¹⁸>Y, A²⁶>E, E³⁵>D, M⁴⁷>L, V⁶⁸>M, A⁷¹>G, D⁹⁰>G) fused, via peptidyl linker ¹⁰⁸GSGGGGS¹¹⁴ to human immunoglobulin G1 Fc fragment (115-345) variant (C¹¹⁹>S, L¹³³>A, L¹³⁴>E, G¹³⁶>A, C-terminal K³⁴⁶ deleted), dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; Homo sapiens T-lymphocyte activation antigen CD80 [CD80, activation B7-1 antigen, CTLA-4 (cytotoxic T-lymphocyte antigen 4) counter-receptor B7.1, B7, BB1] (1-107)-fragment [H¹⁸>Y, A²⁶>E, E³⁵>D, M⁴⁷>L, V⁶⁸>M, A⁷¹>G, D⁹⁰>G]-variant, fused via a GSG4S peptide linker (108-114) to a human immunoglobulin G1 heavy chain constant fragment (Fc) (115-345) [Homo sapiens IGHG1*01; hinge: 115-129 (C¹¹⁹>S); CH2: 130-239 (L¹³³>A, L¹³⁴>E, G¹³⁶>A); CH3: 240-344; CHS: 345-345 (K346del)]; dimer (125-125:128-128')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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