Давутамиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2648058-48-2

immunoglobulin G4-kappa, anti-MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2)], Homo sapiens monoclonal antibody, biparatopic (targeting two different non-overlapping epitopes on MET);
gamma4 heavy chain anti-MET Homo sapiens (1-448) [VH (Homo sapiens IGHV3-9*01 (94.9%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (122-219), hinge 1-12 S10>P (229) (220-231), CH2 L92 (310) (232-341), CH3 (342-446), CHS (447-448)) (122-448)], (135-215')-disulfide with kappa light chain anti-MET Homo sapiens (1'-215') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'-108') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'-215')];
gamma4 heavy chain anti-MET Homo sapiens (1''-444'') [VH (Homo sapiens IGHV3-53*04 (90.6%) -(IGHD) -IGHJ3*02 (93.8%), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1''-117'') -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v8 R115, F116, P125 (CH1 (118''-215''), hinge 1-12 S10>P (225) (216''-227''), CH2 L92 (306) (228''-337''), CH3 H115>R (432), Y116>F (433), L125>P (442) (338''-442''), CHS (443’’-444'')) (118''-444'')], (131''-215''')-disulfide with kappa light chain anti-MET Homo sapiens (1'''-215''') [V-KAPPA (Homo sapiens IGKV1-39*01 (100%) -IGKJ5*01 (100%), CDR-IMGT [6.3.10] (27-32.50-52.89-98)) (1'''-108''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (154), V101 (192) (109'''-215''')]; dimer (227-223'':230-226'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

Поделиться этой страницей