Дебаместроцел

Rec. INN (наименование, зарегистрированное ВОЗ)

DB17934

autologous bone marrow-derived mesenchymal stromal cells (MSC) differentiated to secrete high levels of neurotrophic factors (NTF). The MSCs are isolated from the bone marrow aspirate and cultured in xeno-free growth medium containing 10% platelet lysate. To induce MSC differentiation, the cells are cultured in serum-free media supplemented with dibutyryl cyclic AMP (dbcAMP), human basic fibroblast growth factor (bFGF), human platelet derived growth factor (PDGF-AA), and human heregulin-β1. The cells express mesenchymal progenitor cell marker cluster of differentiation 73 (CD73), CD90, and CD105 (>90%) and secrete high levels of NTF (glial cell line-derived neurotrophic factor (GDNF), brain derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF)), having VEGF (≥7000 pg/10⁶ cells) as the most representative

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