Делпасибарт зотадирсен
Delpacibart zotadirsenМНН
Prop. INN (наименование, предложенное ВОЗ)
CAS
2929240-20-8
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens TFRC (transferrin receptor, TfR1, TFR1, CD71)], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues via a 4-(maleimidomethyl)cyclohexanecarboxamide linker to a single-stranded oligonucleotide (zotadirsen);
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*06 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2, G1v48 CH2 R113 (CH1 R120 (213) (117-214), hinge 1-15 (215-229), CH2 L1.3>A (233), L1.2>A (234), L113>R (327) (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-214)-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (84.2%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (225-225'': 228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atom of an average of four cysteine residues among 219, 225, 288, 214', 219'', 225'', 228'' and 214''' with a group consisting of all-P-ambo-(3RS)-1-({cis- and/or trans-4-[(3-{[2',3'-azanediyl-P,2',3'-trideoxy-P-(dimethylamino)-2',3'-seco](2'-N→5')(C-G-C-C-G-C-C-A-m5U-m5U-m5U-C-m5U-C-A-A-C-A-G-A-m5U-C-m5U-G-m5U-C)-N2'.26-yl}-3-oxopropyl)carbamoyl]cyclohexyl}methyl)-2,5-dioxopyrrolidin-3-yl (zotadirsen)
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-2*06 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v14 CH2 A1.3, A1.2, G1v48 CH2 R113 (CH1 R120 (213) (117-214), hinge 1-15 (215-229), CH2 L1.3>A (233), L1.2>A (234), L113>R (327) (230-339), CH3 E12 (355), M14 (357) (340-444), CHS K2>del (445)) (117-445)], (219-214)-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-NL1*01 (84.2%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (225-225'': 228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; substituted at the sulfur atom of an average of four cysteine residues among 219, 225, 288, 214', 219'', 225'', 228'' and 214''' with a group consisting of all-P-ambo-(3RS)-1-({cis- and/or trans-4-[(3-{[2',3'-azanediyl-P,2',3'-trideoxy-P-(dimethylamino)-2',3'-seco](2'-N→5')(C-G-C-C-G-C-C-A-m5U-m5U-m5U-C-m5U-C-A-A-C-A-G-A-m5U-C-m5U-G-m5U-C)-N2'.26-yl}-3-oxopropyl)carbamoyl]cyclohexyl}methyl)-2,5-dioxopyrrolidin-3-yl (zotadirsen)
Структура
Иностранные названия
- Delpacibartum zotadirsenum (латинское)
- Delpacibart zotadirsen (английское)
- Delpacibart zotadirsen (немецкое)
- Delpacibart zotadirsen (французское)
- Delpacibart zotadirsen (испанское)
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