Денецимиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2488745-86-2

immunoglobulin G4-kappa, anti-[F9 (coagulation factor 9, coagulation factor IX) activated form and F10 (coagulation factor 10, coagulation factor X)], Homo sapiens monoclonal antibody, bispecific, bivalent;
gamma4 heavy chain anti-F9 Homo sapiens (1-448) [VH (Homo sapiens IGHV3-9*01 (89.8%) -(IGHD) -IGHJ5*01 (93.8%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92 (CH1 (123-220), hinge 1-12 S10>P (230) (221-232), CH2 L92 (311) (233-342), CH3 (343-447), CHS K2>del (448)) (123-448)], (136-214')-disulfide with kappa light chain anti-F9 Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-5*03 (91.5%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
gamma4 heavy chain anti-F10 Homo sapiens (1''-446'') [VH (Homo sapiens IGHV5-10-1*01 (92.9%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1''-120'') -Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92 (CH1 (121''-218''), hinge 1-12 S10>P (228) (219''-230''), CH2 L92 (309) (231''-340''), CH3 F85.1>L (405), R88>K (409) (341''-445''), CHS K2>del (446'')) (121''-446'')], (134''-216''')-disulfide with kappa light chain anti-F10 Homo sapiens (1'''-216''') [V-KAPPA (Homo sapiens IGKV3-20*01 (94.7%) -IGKJ2*02 (100%), CDR-IMGT [7.3.10] (27-33.51-53.90-99)) (1'''-109''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (155), V101 (193) (110'''-216''')];
 dimer (228-226'':231-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GS-KO), glycoform alfa

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