Депатуксизумаб мафодотин

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

86278355

DB11731

1585973-65-4

immunoglobulin G1-kappa, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB)], humanized and chimeric monoclonal antibody conjugated to auristatin F;
gamma1 heavy chain humanized (1-446) [humanized VH (Homo sapiens IGHV4-30-4*01 (84.50%) -(IGHD)- IGHJ4*01) [9.7.9] (1-116) -Homo sapiens IGHG1*01, G1m17,1 (CH1 (117-214), hinge (215-229), CH2 (230- 339), CH3 (340-444), CHS (445-446)) (117-446)], (219- 214')-disulfide with kappa light chain chimeric (1'-214') [Mus musculus V-KAPPA (Mus musculus IGKV14-100*01 - IGKJ1*01) [6.3.9] (1'-107') -Homo sapiens IGKC*01, Km3 (108'-214')]; dimer (225-225":228-228")-bisdisulfide; conjugated, on an average of 4 cysteinyl, to monomethylauristatin F (MMAF), via a noncleavable maleimidocaproyl (mc) linker

C₆₆₂₄H₁₀₂₂₈N₁₇₂₈O₂₀₅₂S₄₂

148251,25 г/моль

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