Депемокимаб
DepemokimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2243274-14-6
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens IL5 (interleukin 5, IL-5)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV2-70*19 (75.8%) -(IGHD) -IGHJ4*01 (85.7%)) CDR-IMGT [8.7.13] (26-33.51-57.96-108) (1-119) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v21 CH2 Y15.1, T16, E18 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 M15.1>Y (254), S16>T (256), T18>E (258) (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-220')-disulfide with kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.1%) -IGKJ2*02 (90.9%)) CDR-IMGT [12.3.9] (27-38.56-58.95-103) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114’-220’)]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-K1 cell line lacking the Glutamine Synthetase (GS) gene, glycoform alfa
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV2-70*19 (75.8%) -(IGHD) -IGHJ4*01 (85.7%)) CDR-IMGT [8.7.13] (26-33.51-57.96-108) (1-119) -Homo sapiens IGHG1*03 G1m3, nG1m1, G1v21 CH2 Y15.1, T16, E18 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 M15.1>Y (254), S16>T (256), T18>E (258) (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-220')-disulfide with kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (91.1%) -IGKJ2*02 (90.9%)) CDR-IMGT [12.3.9] (27-38.56-58.95-103) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114’-220’)]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-K1 cell line lacking the Glutamine Synthetase (GS) gene, glycoform alfa
Структура
Иностранные названия
- Depemokimabum (латинское)
- Depemokimab (английское)
- Depemokimab (немецкое)
- Dépémokimab (французское)
- Depemokimab (испанское)
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