Деталимоген вораплазмид

Rec. INN (наименование, зарегистрированное ВОЗ)

2660044-23-3

DNA plasmid encoding codon-optimized human interleukin-12 (IL-12) subunits p40 (β) and p35 (α) joined by a ten amino acid linker sequence (VPGVG)2, under control of a cytomegalovirus (CMV) enhancer- promoter and a bovine growth hormone (bGH) polyadenylation signal, plus two retinoic acid-inducible gene I (RIG-I) agonists (non-protein coding double- stranded RNA eRNA11a and adenovirus VA RNAI) under control of RNA Pol-III promoters. The plasmid also contains an origin of replication, a human T-cell leukemia virus type 1 (HTLV-1) R region, and a β- globin intron

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