Дресбукселимаб
DresbuxelimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
CAS
2550560-20-6
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5' nucleotidase, 5’-NT, NT5, CD73)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (86.7%) L123>T (116), V124>L (117), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-220')-disulfide with kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (89.1%) -IGKJ2*01 (91.7%) Q120>G (106), CDR-IMGT [12.3.9] (27-38.56-58.95-103)) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114'-220')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary
gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ4*01 (86.7%) L123>T (116), V124>L (117), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01, G1m17,1, G1v14 CH2 A1.3, A1.2 (CH1 K120 (218) (122-219), hinge 1-15 (220-234), CH2 L1.3>A (238), L1.2>A (239) (235-344), CH3 D12 (360), L14 (362) (345-449), CHS (450-451)) (122-451)], (224-220')-disulfide with kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (89.1%) -IGKJ2*01 (91.7%) Q120>G (106), CDR-IMGT [12.3.9] (27-38.56-58.95-103)) (1'-113') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (159), V101 (197) (114'-220')]; dimer (230-230'':233-233'')-bisdisulfide, produced in Chinese hamster ovary
Структура
Иностранные названия
- Dresbuxelimabum (латинское)
- Dresbuxelimab (английское)
- Dresbuxelimab (немецкое)
- Dresbuxélimab (французское)
- Dresbuxelimab (испанское)
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