Дротокибарт

Prop. INN (наименование, предложенное ВОЗ)

2925270-26-2

immunoglobulin G4-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, interleukin 13 receptor, CD124)], humanized monoclonal antibody;
H-gamma4 heavy chain humanized (1-445) [VH (Homo sapiens IGHV3-48*01 (88.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (119-216), hinge 1-12 S10>P (226) (217-228), CH2 L92 (307) (229-338), CH3 (339-443), CHS (444-445)) (119-445)], (132-215')-disulfide with L-kappa light chain humanized (1'-215') [V-KAPPA (Homo sapiens IGKV3D-11*02 (88.9%) -IGKJ4*01 (100%), CDR-IMGT [5.3.11] (27'-31'.49'-51'.88'-98')) (1'-108') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (154'), V101 (192')) (109'-215')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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