Дувортуксизумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB15211

1831098-91-9

immunoglobulin G1 scFv-h-CH2-CH3(_scFv)_h-CH2-CH3, bispecific, anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)] and anti-[Homo sapiens CD3 epsilon (CD3E, Leu-4)], humanized and chimeric monoclonal antibody;
scFv-h-CH2-CH3 chain (1-502) [humanized V-KAPPA antiCD19 (IGKV3D-11*02 (79.30%) -IGKJ2*02) [5.3.9] (1- 106)-8-mer triglycyl-seryl-tetraglycyl linker (107-114) -Mus musculus VH anti-CD3 (IGHV10-1*02 (88.90%) -(IGHD) - IGHJ3*01) [8.10.16] (115-239)-5-mer alanyl-seryl-threonyllysyl-glycyl linker (240-244) -E-coil motif (245-272) -3-mer triglycyl linker (273-275) -Homo sapiens IGHG1*03, nG1m1 hinge-CH2-CH3 (hinge 6-15 (276-285), CH2 L1.3>A (289), L1.2>A (290) (286-395), CH3 E12 (411), M14 (413), T22>W (421) (knob) (396-500), CHS (501- 502)) (276-502)];
(249-248')-disulfide with the scFv chain (1'-271') [Mus musculus V-LAMBDA anti-CD3 (IGLV1*01 (81.20%) - IGKJ1*01) [9.3.9](1'-109') -9-mer tetraglycyl-seryltetraglycyl linker (110'-118') -humanized VH anti-CD19 (Homo sapiens IGHV2-5*08 (90.80%) -(IGHD) -IGHJ4*01 L123>T (233) [10.7.12](119'-238') -5-mer alanyl-serylthreonyl-lysyl-glycyl linker -(239'-243') -K-coil motif(244'- 271')];
(281-6'':284-9'')-bisdisulfide with the Homo sapiens IGHG1*03, nG1m1 hinge-CH2-CH3 chain (1-227) [hinge 6- 15 (1-10), CH2 L1.3>A (4), L1.2>A (5) (11-120), CH3 E12 (136), M14 (138), T22>S (146) / L24>A (148) / Y86>V (187) (hole), H115>R (215) (121-225), CHS (226-227)]

>C₄₈₅₀H₇₄₈₅N₁₃₀₅O₁₄₈₇S₃₅

108989,98 г/моль

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