Эбрибафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2839652-75-2

chimeric immunoglobulin G4-kappa anti-(human complement C3d) fused at the C-terminus of the heavy chain, via a (G4S)2 peptide linker to human complement factor H fragment, glycoform alfa;
gamma 4 heavy chain (1-437) [VH (Homo sapiens IGHV1-46*01 -(IGHD) - IGHJ4*01, CDR-Kabat [5.17.2] (31-35.50-66.99-100)) (1-111) -Homo sapiens IGHG4*01 (CH1 (112-209), hinge S²¹⁹>P (210-221), CH2 L²²⁶>E (222-331), CH3 M⁴¹⁹>L, N⁴²⁵>S (332-436), CHS K⁴³⁸>del (437)) (112-437)] fused via a (G₄S)₂ peptide linker (438-447) to human complement factor H fragment 19-323 (448-752 in the current sequence, containing the first five consensus repeat Sushi domains, residues 19-322, plus the adjacent K322), (125-219')-disulfide with kappa light chain (1'-219') [V-KAPPA (Homo sapiens IGKV2-30*01 -IGKJ4*01, CDR-Kabat [16.7.9] (24'-39'.55'-61'.94'- 102')) (1'-112') -Homo sapiens IGKC*01 (113'-219')]; dimer (217-217'':220- 220'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-M, glycoform alfa

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