Эцискафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2649758-52-9

humanized immunoglobulin G1-kappa anti-(human PDCD1 (programmed cell death protein 1, PD-1, CD279)) fused at the C-terminus of one heavy chain (1-449), variant (L237>A, L238>A, P332>G, S357>C, T369>W, C-terminal K⁴⁵⁰ deleted), via the peptide linker ⁴⁵⁰GGGGSGGGGSGGGGS⁴⁶⁴, to human interleukin 2 (IL2) (465-597), variant (T³>A⁴⁶⁷, F⁴²>A⁵⁰⁶, Y⁴⁵>A⁵⁰⁹, L⁷²>G⁵³⁶, C¹²⁵>A⁵⁸⁹), disulfide bridged to gamma1 heavy chain (1-450), variant (L237''>A, L238''>A, P332''>G, Y352''>C, T369''>S, L371''>A, Y410''>V) with each gamma1 chain disulfide bridged to the same kappa light chain, heterodimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; humanized immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death protein 1, PD-1, PD1, CD279)], fused at the C-terminus of one heavy chain, via a (G4S)3 peptide linker with one interleukin 2 mutant chain, glycoform alfa: gamma1 heavy chain (1-449) [VH (Homo sapiens IGHV3- 23*01 -(IGHD) -IGHJ5*01, CDR-Kabat [5.17.11] (31-35.50- 66.99-109)) (1-120) -Homo sapiens IGHG1*01 CH1 (121-218), hinge (219-233), CH2 L²³⁷>A, L²³⁸>A, P³³²>G, (234-343), CH3 S³⁵⁷>C, T³⁶⁹>W (344-448), CHS K⁴⁵⁰>del (449)] fused via a (G4S)3 peptide linker (450-464) with interleukin 2 (IL2, human), [T³>A⁴⁶⁷, F⁴²>A⁵⁰⁶, Y⁴⁵>A⁵⁰⁹, L⁷²>G⁵³⁶, C¹²⁵>A⁵⁸⁹]-mutant (465- 597), (223-218')-disulfide with kappa light chain (1'-218') [V- KAPPA (Homo sapiens IGKV4-1*01 -IGKJ1*01, CDR-Kabat [15.7.9] (24'-38'.54'-60'.93'-101')) (1'-111') -Homo sapiens IGKC*01 (112'-218')], (229-229'':232-232'', 357-352'')-trisdisulfide heterodimer with gamma1 heavy chain (1''-450'') [VH (Homo sapiens IGHV3-23*01 -(IGHD) -IGHJ5*01, CDR- Kabat [5.17.11] (31''-35''.50''-66''.99''-109'')) (1''-120'') -Homo sapiens IGHG1*01 CH1 (121''-218''), hinge (219''-233''), CH2 L²³⁷>A, L²³⁸>A, P³³²>G (234''-343''), CH3 Y³⁵²>C, T³⁶⁹>S, L³⁷¹>A, Y⁴¹⁰>V (344''-448'') CHS (449''-450'')], (223''-218''')-disulfide with kappa light chain (1'''-218''') [V-KAPPA (Homo sapiens IGKV4- 1*01 -IGKJ1*01, CDR-Kabat [15.7.9] (24'''-38'''.54'''-60'''.93'''- 101''')) (1'''-111''') -Homo sapiens IGKC*01 (112'''-218''')], produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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