Эфариндодекин альфа

Prop. INN (наименование, предложенное ВОЗ)

2922072-00-0

Fc fragment of human immunoglobulin G1 (1-227) [Homo sapiens IGHG1*01, hinge (1-10), CH2 N⁷⁷>A (11-120), CH3 S¹³⁴>C, T¹⁴⁶>W (121-225), CHS K²²⁷>G (226-227)] fused via peptide linker ²²⁸GSGGSGGSISSGLLSGRSSGP²⁴⁸ to human interleukin-12 subunit beta [IL-12B, cytotoxic lymphocyte maturation factor p40 (CLMF p40), IL-12 subunit p40, NK cell stimulatory factor 2 (NKSF2)] (1- 306, 249-552 in the current sequence), variant (C²⁵²>S⁵⁰⁰, ²⁵⁹SKR²⁶¹>⁵⁰⁷DNT⁵⁰⁹, ²⁶³KK²⁶⁴>del, D²⁶⁵>G⁵¹¹) fused via peptide linker 553GGGGSGGGGSGGGGS567 to human interleukin-12 subunit alpha [IL-12A, cytotoxic lymphocyte maturation factor p35 (CLMF p35), IL-12 subunit p35, NK cell stimulatory factor 1 (NKSF1)] (1-197, 568-764 in the current sequence); (6-6', 9-9', 134-129')-trisdisulfide bridged to Fc fragment of human immunoglobulin G1 (1'-227') [Homo sapiens IGHG1*01, hinge (1'-10'), CH2 N⁷⁷'>A (11'-120'), CH3 Y¹²⁹'>C, T¹⁴⁶'>S, L¹⁴⁸'>A, Y¹⁸⁷'>V (121'-225'), CHS K²²⁷'>G (226'-227')] fused via peptide linker ²²⁸'GSGGGSG²³⁴' to human interleukin 12 receptor subunit beta 2 (IL12RB2) fragment (1-296, 235'-530' in the current sequence), variant (C²¹⁹>S⁴⁵³'), heterodimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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