Эфбалропендекин альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2736449-62-8

human interleukin-15 (IL-15) fragment (1-114) variant (D³⁰>N, E⁶⁴>Q, N⁶⁵>D) fused via peptide linker ¹¹⁵GGGGS¹¹⁹ to a human immunoglobulin G1 C-terminal Fc fragment (120-350) variant, [Homo sapiens IGHG1*03; hinge: 120-134 (C124S); CH2: 135-243 (E137P, L138V, L139A, G139-140del, S170K, Q198E whereby E137P, L138V, L139A, G139-140del matches IGHG2*02); CH3: 244-348 (L271D, K273S, N287D, Q321E, N324D, M331L, N337S); CHS: 349-350], disulfide bridge with human interleukin-15 receptor subunit alpha fragment (1-65) fused via the ⁶⁶GGGGS⁷⁰ peptide linker to a human immunoglobulin G1 Fc fragment (71-301) variant [Homo sapiens IGHG1*03; Hinge: 71-85 C75S); CH2: 86-194 (E88P, L89V, L90A, G90-91del, S121K); CH3: 195-299 (E211Q, S218K, M282L, N288S); CHS: 300-301], disulfide bridged heterodimer, produced in Chinese hamster ovary (CHO-M) cells, glycoform alfa

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