Эферколейкин альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2760549-52-6

human immunoglobulin G1 Fc fragment (h-CH2-CH3-CHS domains [Homo sapiens IGHG1*01 (hinge (1-10), CH2 N⁷⁷>A (11-120), CH3 Y¹²⁹>C, T¹⁴⁶>S, L¹⁴⁸>A, Y¹⁸⁷>V (121-225), CHS K²²⁷>del (226-226))]) (1-226), fused via the peptide linker ²²⁷GPPSGSSPMPYDLYHPSGGG²⁴⁶  to interleukin 2 receptor subunit beta (IL2RB, high affinity IL-2 receptor subunit β, CD122) fragment (27-239, 247-459 in the current sequence), variant (C¹²²>S³⁶⁸, C¹⁶⁸>S⁴¹⁴), disulfide bridged to human immunoglobulin G1 Fc fragment (h-CH2-CH3-CHS domains [Homo sapiens IGHG1*01 (hinge (1'-10'), CH2 N⁷⁷'>A (11'-120'), CH3 S¹³⁴'>C, T¹⁴⁶'>W (121'-225'), CHS K²²⁷'>del (226'- 226'))]), fused via peptide linker ²²⁷GGSSPPGGGSSGGGSGP²⁴³ to human interleukin 2 (IL2) (21-153, 244-376 in the current sequence), variant (R⁵⁸>A²⁸¹', F⁶²>A²⁸⁵', Y⁶⁵>A²⁸⁸', E⁸²>A³⁰⁵', C145>A368'), heterodimer, produced in Chinese hamster ovary (CHO) K1 cells, glycoform alfa

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