Эфоципегтрутид

Rec. INN (наименование, зарегистрированное ВОЗ)

2513399-19-2

chimeric triple receptor agonist peptide (1''-40''), sharing balanced sequence homology with glucagon, glucagon-like peptide 1 (GLP1) and gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic polypeptide, incretin hormone), produced by chemical synthesis, conjugated at the S atom of the C-terminal cysteinamide 40'' via a polyethylene glycol linker (~10 kDa) to the N atom of one N-terminal proline residue of the dimer (3-3')-disulfide of an immunoglobulin G4 (IgG4) heavy chain constant fragment (Fc, C-terminal 221-peptide, produced in Escherichia coli, not glycosylated):
N^1.1-(3-{α-[3-(3-{(3RS)-3-[16,20-anhydro(L-tyrosyl-2-methylalanyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-α-glutamyl-L-lysyl-L-arginyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-leucyl-L-α-aspartyl-L-histidyl-L-histidyl-L-prolyl-L-seryl-L-serylglycyl-L-glutaminyl-L-prolyl-L-prolyl-L-prolyl-L-seryl-L-cysteinamide)-S^3.40-yl]-2,5- dioxopyrrolidin-1-yl}propanamido)propyl]poly(oxyethylene)-ω-oxy}propyl)(IgG4 Fc (Homo sapiens IGHG4*01 (hinge (1-4, N-terminal hinge residues ESKYGPPC deleted), CH2 (5-114), CH3 (115-219), CHS (220-221))(1-221) dimer (3-3')-disulfide)

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