Эфзилонкофусп альфа

Prop. INN (наименование, предложенное ВОЗ)

2922216-50-8

human T-lymphocyte activation antigen CD80 (activation B7-1 antigen, CTLA-4 counter-receptor B7.1, CD80) extracellular domain containing fragment (1-208 in the current sequence) fused via peptide linker ²⁰⁹GSGGGGSGGGGSGGGGS²²⁵ to an Fc fragment of human immunoglobulin G4 (226-454) [Homo sapiens IGHG4*01, hinge ins²²⁶>A, S²³⁶>P (226-238), CH2 F²⁴²>A, L²⁴³>A, T²⁵⁸>Q (239-348), CH3 M⁴³⁶>L (349-453), CHS K⁴⁵⁵>del (454)] fused via peptide linker ⁴⁵⁵GGGGS⁴⁵⁹ to human interleukin-2 (IL-2, T-cell growth factor (TCGF)) (1-133, 460-592 in the current sequence), variant (R³⁸>A⁴⁹⁷, F⁴²>A⁵⁰¹, E⁶¹>R⁵²⁰) dimer (234-234', 237-237')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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