Элувикстамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens CD33 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain (scFv)2-scFc, bispecific;
IG scFv-scFv-scFc single chain, anti-CD33 and anti-CD3E (1-993) [scFv-VH-V-kappa anti-CD33 (1-250) [VH (Homo sapiens IGHV1-18*01 G49>C (44) (81.6%) -(IGHD) -IGHJ4*01 (93.3%)) CDR-IMGT [8.8.15] (26-33.51-58.97-111) (1-122) -15-mer tris(tetraglycyl-seryl) linker (123-137) -V-KAPPA (Homo sapiens IGKV4-1*01 (83.2%) -IGKJ5*01 Q120>C (243) (91.7%)) CDR-IMGT [12.3.9] (164-175.193-195.232-240) (138-250)] -6-mer seryl-tetraglycyl-seryl linker (251-256) -scFv-VH-V-lambda anti-CD3E (257-505) [VH (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87%) -(IGHD) -IGHJ5*01 (100%)) CDR-IMGT [8.10.16] (282-289.307-316.355-370) (257-381) -15-mer tris(tetraglycyl-seryl) linker (382-396) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%)) CDR-IMGT [9.3.9] (422-430.448-450.487-495) (397-505)] -4-mer tetraglycyl linker (506-509) -scFc (h-CH2-CH3)-(h-CH2-CH3) (510-993) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (510-519), CH2 R83>C (581), N84.4>G (586), V85>C (591) (520-629), CH3 E12 (645), M14 (647) (630-734), CHS (735-736)) (510-736) -30-mer hexakis(tetraglycyl-seryl) linker (737-766) -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1 (hinge 6-15 (767-776), CH2 R83>C (838), N84.4>G (843), V85>C (848) (777-886), CH3 E12 (902), M14 (904) (887-991), CHS (992-993)) (767-993)]], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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