Эмфизатамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2559704-23-1

immunoglobulin scFv-G1-scFv-scFv_L-kappa, anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], anti-[Homo sapiens CD19 (B lymphocyte surface antigen B4, Leu-12)], anti-[Homo sapiens CD274 (programmed death ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1)] and anti-[Homo sapiens TNFRSF9 (tumor necrosis factor receptor (TNFR) superfamily member 9, 4-1BB, CD137)], Homo sapiens and humanized monoclonal antibody, tetraspecific;
scFv-G1-scFv-scFv fused heavy chain Homo sapiens and humanized (1-1230) [scFv kappa-heavy anti-CD3E humanized (1-252) [V-KAPPA (Homo sapiens IGKV1-5*01 (90.1%) -IGKJ4*01 (90.9%), CDR-IMGT [6.3.14] (27-32.50-52.89-102)) (1-112) -20-mer tetrakis(tetraglycyl-seryl) linker (113-132) -VH (Homo sapiens IGHV3-66*01 (86.6%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.14] (158-165.183-189.228-241)) (133-252)] -10-mer bis(tetraglycyl-seryl) linker (253-262) -gamma-1 heavy chain anti-CD19 Homo sapiens (263-712) [VH (Homo sapiens IGHV5-51*01 (94.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.14] (288-295.313-320.359-372)) (263-383) -Homo sapiens IGHG1*03, G1m3, nG1m1, G1v14 CH2 A1.3, A1.2, G1v20 CH2 A105 (CH1 R120 (480) (384-481), hinge 1-15 (482-496), CH2 L1.3>A (500), L1.2>A (501), G1>A (503), K105>A (588) (497-606), CH3 D12 (622), L14 (624) (607-711), CHS K2>del (712)) (384-712)] -10-mer bis(tetraglycyl-seryl) linker (713-722) -scFv heavy-kappa anti-CD274 humanized (723-974) [VH (Homo sapiens IGHV3-23*01 (84.0%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [9.8.13] (748-756.774-781.821-833)) (723-844) -20-mer tetrakis(tetraglycyl-seryl) linker (845-864) -V-KAPPA (Homo sapiens IGKV1-5*03 (91.5%) -IGKJ4*01 (100%), CDR-IMGT [6.3.12] (891-896.914-916.953-964)) (865-974)] -10-mer bis(tetraglycyl-seryl) linker (975-984) -scFv heavy-kappa anti-TNFRSF9 humanized (985-1230) [VH (Homo sapiens IGHV3-64*04 (82.1%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.10] (1009-1016.1034-1040.1079-1088)) (985-1099) -20-mer tetrakis(tetraglycyl-seryl) linker (1100-1119) -V-KAPPA (Homo sapiens IGKV1-12*01 (83.1%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (1146-1151.1169-1171.1208-1220)) (1120-1230)]]; (486-214')-disulfide with kappa light chain anti-CD19 Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV1-13*02 (100%) -IGKJ3*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (492-492'':495-495'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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