Эмиродатамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2449199-61-3

immunoglobulin scFv-scFv-scFc, anti-[Homo sapiens FLT3 (fms related receptor tyrosine kinase 3, STK1, FLK2, CD135)] and anti-[Homo sapiens CD3E (CD3e, CD3 epsilon)], single chain monoclonal antibody, bispecific;
scFv-scFv-scFc fused single chain (1-989) [scFv heavy-kappa anti-FLT3 (1-246) [VH (Homo sapiens IGHV2-26*03 (92.0%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [10.7.16] (26-35.53-59.98-113)) (1-124) -15-mer tris(tetraglycyl-seryl) linker (125-139) -V-KAPPA (Homo sapiens IGKV1-17*01 (98.9%) -IGKJ4*01 (91.7%) G120>C (239), CDR-IMGT [6.3.9] (166-171.189-191.228-236)) (140-246)] -6-mer seryl-tetraglycyl-seryl linker (247-252) -scFv heavy-lambda anti-CD3E (253-501) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (92.9%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ5*01 (100%), CDR-IMGT [8.10.16] (278-285.303-312.351-366)) (253-377) -15-mer tris(tetraglycyl-seryl) linker (378-392) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (418-426.444-446.483-491)) (393-501)] -4-mer tetraglycyl linker (502-505) -scFc gamma1 (h-CH2-CH3)-(h-CH2-CH3) (506-989) [Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (506-515), CH2 R83>C (577), N84.4>G (582), V85>C (587) (516-625), CH3 E12 (641), M14 (643) (626-730), CHS (731-732)) (506-732)] -30-mer hexakis(tetraglycyl-seryl) linker (733-762) -Homo sapiens IGHG1*03 h-CH2-CH3, nG1m1, G1v30 CH2 N84.4>G (hinge 6-15 (763-772), CH2 R83>C (834), N84.4>G (839), V85>C (844) (773-882), CH3 E12 (898), M14 (900) (883-987), CHS (988-989)]], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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