Эмугробарт

Prop. INN (наименование, предложенное ВОЗ)

2922218-19-5

immunoglobulin G1-kappa, anti-[Homo sapiens MSTN (myostatin, growth differentiation factor 8, GDF8, GDF-8) latent myostatin complex], humanized monoclonal antibody;
H-gamma1 heavy chain humanized (1-447) [VH (Homo sapiens IGHV3-66*01 (69.1%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH2 E12, M14, G1v86 CH2 Y1.3, D2, I26, K115, G1v87 V14, P90, G1v88 CH2 R94, CH3 R1.2, G1v89 CH3 T116, R118, G1v78-1 CH3 L107, A114, T116 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2  L1.3>Y (236), P2>D (240), T14>V (252), V26>I (266), T90>P (309), Q94>R (313), A115>K (332) (233-342), CH3 E12 (358), M14 (360), P1.2>R (345), M107>L (430), N114>A (436), Y116>T (438), Q118>R (440), S120>E (442) (343-447), CHS G1>del, K2>del) (120-447)], (222-217')-disulfide with L-kappa light chain humanized (1'-217') [V-KAPPA (Homo sapiens IGKV3D-7*01 (77.7%) -IGKJ2*02 (90.0%) L124>V (107'), CDR-IMGT [8.3.10] (27'-34'.52'-54'.91'-100')) (1'-110') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (156'), V101 (194')) (111'-217')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DXB11, glycoform alfa

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