Эмункитуг

Prop. INN (наименование, предложенное ВОЗ)

2916519-48-5

immunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF1B (tumor necrosis factor receptor (TNFR) superfamily member 1B, TNFR2, TNFR type II, p75, CD120b)], humanized monoclonal antibody, agonist;
H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV1-46*04 (83.5%) -(IGHD) -IGHJ6*01 (92.3%) Q120>T (110), CDR-IMGT [8.8.11] (26-33.51-58.97-107)) (1-118) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-213')-disulfide with L-kappa light chain humanized (1'-213') [V-KAPPA (Homo sapiens IGKV1-9*01 (81.1%) -IGKJ2*01 (90.9%) Q120>S (99), CDR-IMGT [5.3.9] (27'-31'.49'-51'.88'-96')) (1'-106') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (152'), V101 (190')) (107'-213')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-DG44, glycoform alfa

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