Энкоберминоген резмаденовек

Rec. INN (наименование, зарегистрированное ВОЗ)

A replication-deficient recombinant adenovirus, serotype 5, encoding multiple human vascular endothelial growth factor (VEGF) isoforms. A replication-deficient recombinant adenovirus, serotype 5 (Ad5), encoding multiple human vascular endothelial growth factor (VEGF) isoforms (VEGF121, VEGF165 and VEGF189) under the control of a cytomegalovirus immediate early promoter/enhancer (CMV) and the simian virus 40 (SV40) polyA sequence. Alternative splicing provides mRNA that encodes the three major isoforms of VEGF: VEGF121 (exons 1-5 and 8), VEGF165 (exons 1-5, 7 and 8) and VEGF189 (exons 1-5, 6A, 7 and 8). The VEGF transgene is inserted into the region from which the adenovirus early gene E1A is deleted and E1B is partially deleted; the E3 gene is deleted between late gene L5 and the early gene E4.

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