Энекинраген инзаденовек

Rec. INN (наименование, зарегистрированное ВОЗ)

2618581-50-1

recombinant, non-replicating adenovirus type 5 (Ad5) vector encoding codon-optimised human interleukin 1 receptor antagonist (IL-1Ra) under the control of an engineered nuclear factor kappa B (NF-κB) inducible promoter composed of five conserved NF-κB binding motif repeats fused to a proximal promoter region of the human endothelial leukocyte adhesion molecule (ELAM) gene (NF-κB5-ELAM), and terminated by a simian virus 40 (SV40) polyadenylation sequence. The vector genome is flanked by human Ad5 inverted terminal repeats (ITRs) and the bulk of the adenovirus genome has been replaced by a non-coding human hypoxanthine phosphoribosyltransferase (HPRT) stuffer sequence and by a human non-coding cosmid insert containing the polymorphic marker DXS455.

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