Энибарцимаб
EnibarcimabМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
immunoglobulin G1-kappa, anti-[Homo sapiens ADM (adrenomedullin)], monoclonal antibody;
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV1-69*01 (86.5%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-219')-disulfide with kappa light chain (1'-219') [V-KAPPA (Mus musculus IGKV1-117*01 (88.0%) -IGKJ2*01 (100%)/Homo sapiens IGKV2-30*01 (88.0%) -IGKJ2*01 (91.7%)) CDR-IMGT [11.3.9] (27-37.55-57.94-102) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113’-219’)];
dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-DG44 cell line, glycoform alfa
gamma1 heavy chain (1-448) [VH (Homo sapiens IGHV1-69*01 (86.5%) -(IGHD) -IGHJ4*01 (92.9%)) CDR-IMGT [8.8.11] (26-33.51-58.97-107) (1-118) -Homo sapiens IGHG1*01 (100%) G1m17,1 (CH1 K120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 D12 (357), L14 (359) (342-446), CHS (447-448)) (119-448)], (221-219')-disulfide with kappa light chain (1'-219') [V-KAPPA (Mus musculus IGKV1-117*01 (88.0%) -IGKJ2*01 (100%)/Homo sapiens IGKV2-30*01 (88.0%) -IGKJ2*01 (91.7%)) CDR-IMGT [11.3.9] (27-37.55-57.94-102) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113’-219’)];
dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese Hamster Ovary (CHO)-DG44 cell line, glycoform alfa
Структура
Иностранные названия
- Enibarcimabum (латинское)
- Enibarcimab (английское)
- Enibarcimab (немецкое)
- Énibarcimab (французское)
- Enibarcimab (испанское)
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