Энристомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

2539845-73-1

immunoglobulin VH-VH'-G1(h-CH2-CH3) heavy chain dimer, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)] and anti-[Homo sapiens TNFRSF9 (TNF receptor superfamily member 9, 4-1BB, T-cell antigen ILA, CD137)], monoclonal antibody humanized, bispecific, tétravalent;
IG VH-VH'-G1(h-CH2-CH3) heavy chain humanized (1-466) [VH anti-CD274 humanized (Homo sapiens IGHV3-23*01 (78.1%) -(IGHD) -IGHJ4*01 (81.8%) S127>K (110), S128>P (111), CDR-IMGT [8.7.5] (26-33.51-57.96-100)) (1-111) -6-mer bis(diglycyl-seryl) linker (112-117) -VH' anti-TNFRSF9 humanized (Homo sapiens IGHV3-23*01 (80.2%) -(IGHD) -IGHJ4*01 (81.8%) S127>K (237), S128>P (238), CDR-IMGT [8.7.15] (143-150.168-174.213-227)) (118-238) -4-mer tetraglycyl linker (239-242) -Homo sapiens IGHG1*01 h-CH2-CH3 (100%), G1m1 CH3 D12, L14 G1v71 CH2 ELL1-4-1.2>del (hinge 6-15 (243-252), CH2 ELL1.4-1.2>del (254^255) (253-359), CH3 D12 (375), L14 (377) (360-464), CHS (465-466)) (243-466)]; dimer (248-248':251-251')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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