Эрамкафусп альфа

Rec. INN (наименование, зарегистрированное ВОЗ)

2388499-82-7

chimeric immunoglobulin G1-kappa anti-(human B- lymphocyte antigen CD20) (rituximab (77)(39)), fused at the C-terminus of both heavy chains (1-451) via peptidyl linker ⁴⁵²SGGGGS⁴⁵⁷ to human interferon a- 2b (IFNa-2b) fragment (24-188, 458-622 in the current sequence) variant (²³K>R⁴⁸⁰), dimer, glycosylated, produced in Chinese hamster ovary (CHO) cells;
immunoglobulin G1-kappa, anti-[Homo sapiens CD20 antigen (B-lymphocyte antigen CD20)], humanized monoclonal antibody (rituximab (77)(39)), gamma1 heavy chain humanized (1-451) [Mus musculus IGHV1-12*01; Mus musculus IGHJ1*01; Homo sapiens IGHG1*01; VH: 1-121; CH1: 122-219; hinge 220-234; CH2: 235-344; CH3: 345-449; CHS: 450­451; CDRKabatH1: SYNMH (31-35); CDRKabatH2: AIYPGNGDTSYNQKFKG (50-66); CDRKabatH3: STYYGGDWYFNV (99-110)], fused via a SG4S linker (452-457) with interferon a-2b (Homo sapiens) [K²³>R⁴⁸⁰]-variant (458-622), (224-213')-disulfide with kappa light chain humanized (1'-213') [Mus musculus IGKJ1*01; Homo sapiens IGKC*01; VL: 1-111; CL: 112-218; CDRKabatL1: RASSSVSYIH (24-33);
CDRKabatL2: ATSNLAS (49-55); CDRKabatL3: QQWTSNPPT (88-96)]; dimer (230-230":233-233")- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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