Эсонадоген имвопарвовек

Rec. INN (наименование, зарегистрированное ВОЗ)

2678565-23-4

recombinant, non-replicating adeno-associated virus serotype 2 (AAV2) vector encoding codon-optimised human NADH dehydrogenase subunit 4 (also known as NADH-ubiquinone oxidoreductase chain 4; MTND4, NADH4, ND4) preceded by a Kozak sequence and a mitochondrial targeting sequence from human heme A: farnesyltransferase cytochrome C oxidase assembly factor (also known as protoheme IX farnesyltransferase, mitochondrial; gene COX10), under control of a human cytomegalovirus enhancer/promoter plus a Macacine herpesvirus-3 chimeric intron, followed with a COX10 gene 3'- untranslated region (UTR), and terminated by a simian virus 40 (SV40) polyadenylation signal, and flanked by AAV2 inverted terminal repeats (ITRs)

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