Этентамиг

Prop. INN (наименование, предложенное ВОЗ)

2490552-52-6

immunoglobulin G4-kappa, anti-[Homo sapiens CD3E (CD3 epsilon)] and anti-[Homo sapiens TNFRSF17 (TNF receptor superfamily member 17, BCMA, TNFRSF13A, CD269)], Homo sapiens and humanized monoclonal antibody, bispecific, trivalent;
gamma4 heavy chain anti-CD3E Homo sapiens (1-450) [VH (Homo sapiens IGHV3-9*01 (100%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2, G1v32 CH3 W22 (knob) (CH1 (124-221), hinge 1-12 S10>P (231) (222-233), CH2 F1.3>A (237), L1.2>A (238), L92 (312) (234-343), CH3 T22>W (369) (344-448), CHS (449-450)) (124-450)], (137-214')-disulfide with a fixed kappa light chain Homo sapiens (1'-214') [V-KAPPA (Homo sapiens IGKV3-15*01 (100%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')];
gamma4 heavy chain anti-TNFRSF17 humanized, bivalent (1''-472'') [VH humanized (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ1*01 W118>R (109) (85.7%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1''-119'') -5-mer tetraglycyl-seryl linker (120''-124'') -[VH humanized (Homo sapiens IGHV3-23*01 (93.9%) -(IGHD) -IGHJ1*01 W118>R (233) (85.7%), CDR-IMGT [8.8.12] (150-157.175-182.221-232)) (125''-243'') -Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10, G4v4 CH2 A1.3, A1.2, G1v33 CH3 S22, A24, V86 (hole) (hinge 1-12 S10>P (253) (244''-255''), CH2 F1.3>A (259), L1.2>A (260), L92 (334) (256''-365''), CH3 T22>S (391), L24>A (393), Y86>V (432) (366''-470''), CHS (471’’-472'')) (244''-472'')]; dimer (229-251'':232-254'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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