Этевритамаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2329692-74-0

immunoglobulin scFv-scFv, anti-[Homo sapiens EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB) variant III (EGFRvIII)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody single chain, bispecific;
IG scFv-scFv single chain (1-512) [scFv-VH-V-kappa anti-EGFRvIII (1-251) [VH (Homo sapiens IGHV3-33*01 G49>C (44) (93.9%) -IGHD) -IGHJ4*01 (100%)) CDR-IMGT [8.8.17] (26-33.51-58.97-113) (1-124) -15-mer tris(tetraglycyl-seryl) linker (125-139) -V-KAPPA (Homo sapiens IGKV2-24*01 (92.0%) -IGKJ1*01 Q120>C (244) (90.9%)) CDR-IMGT [11.3.9] (166-176.194-196.233-241) (140-251)] -6-mer seryl-tetraglycyl-seryl linker (252-257) -scFv-VH-V-lambda anti-CD3E (258-506) [VH (Mus musculus IGHV10-1*02 (91.9%) -(IGHD) -IGHJ3*01 (86.7%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ5*01 (100%)) [8.10.16] (258-382) – 15-mer tris(tetraglycyl-seryl) linker (383-397) -V-LAMBDA (Homo sapiens IGLV7-43*01 (85.1%) -IGLJ3*02 (100%) CDR-IMGT [9.3.9] (423-431.449-451.488-496) (398-506)] -hexahistidine (507-512)], produced in Chinese hamster ovary (CHO) cells, non-glycosylated

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