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Prop. INN (наименование, предложенное ВОЗ)

3009874-10-3

immunoglobulin L-kappa-H-gamma1_L-lambda-H-gamma1, anti-[Homo sapiens NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1, B7 homolog 6, B7-H6)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], monoclonal antibody, bispecific;
fused chain L-kappa-H-gamma1 anti-NCR3LG1 (1-698) (knob) [L-kappa anti-NCR3LG1 (1-214) [V-KAPPA (Homo sapiens IGKV1-16*01 (85.3%) -IGKJ2*01 (90.9%) Q120>A (100), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')] -38-mer (tetraglycylseryl-bis(EGKSSGSGSESKST)-tetraglycylseryl) linker (215-252) -[H-gamma-1 heavy chain anti-NCR3LG1 (253-698) [VH (Homo sapiens IGHV1-46*01 (81.6%) -(IGHD) -IGHJ5*01 (92.3%), CDR-IMGT [8.8.10] (278-285.303-310.349-358)) (253-369) -Homo sapiens IGHG1*03, G1m3, nG1m1, CH1 R120, CH3 E12, M14, 6-G1v14 CH2 A1.3, A1.2, 14-G1v32 CH3 W22 (knob) (CH1 R120 (466) (370-467), hinge 1-15 (468-482), CH2 L1.3>A (486), L1.2>A (487) (483-592), CH3 E12 (608), M14 (610), T22>W (618) (593-697), CHS K2>del (698)) (370-698)]];
fused chain L-lambda6-H-gamma1 anti-CD3E (1-707) (hole) [L-lambda6 anti-CD3E (1'-215') [V-LAMBDA Musmus/Homsap (Mus musculus IGLV1*01 (82.3%) -IGLJ1*01 (100%)/Homo sapiens IGLV7-46*01 (76.8%) -IGLJ3*02 (100%), CDR-IMGT [9.3.9] (26'-34'.52'-54'.91'-99')) (1'-109') -Homo sapiens IGLC6*01 (100%) (C-LAMBDA6) (110'-215')] -38-mer (tetraglycylseryl-bis(EGKSSGSGSESKST)-tetraglycylseryl) linker (216'-253') -[H-gamma-1 anti-CD3E (254'-707') [VH Musmus/Homsap (Mus musculus IGHV10-1*04 (93.0%) -(IGHD) -IGHJ3*01 (100%)/Homo sapiens IGHV3-73*01 (87.0%) -(IGHD) -IGHJ6*01 (81.8%) T123>L (373'), S128>A (378'), CDR-IMGT [8.10.16] (279'-286'.304'-313'.352'-367')) (254'-378') -Homo sapiens IGHG1*03, G1m3, nG1m1, CH1 R120, CH3 E12, M14, 6-G1v14 CH2 A1.3, A1.2, 14-G1v33 CH3 S22, A24, V86 (hole), 10-G1v83 CH3 R115, F116 (CH1 R120 (475') (379'-476'), hinge 1-15 (477'-491'), CH2 L1.3>A (495'), L1.2>A (496') (492'-601'), CH3 E12 (617'), M14 (619'), T22>S (627'), L24>A (629'), Y86>V (668'), H115>R (696'), Y116>F (697') (602'-706'), CHS K2>del (707')) (379'-707')]]; dimer (478-487':481-490')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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