Эвенкалеуцел
EvencaleucelМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
autologous lymphocytes enriched in activated natural killer cells (NK), derived from peripheral blood mononuclear cells (PBMCs).
The cells are cultured in medium supplemented with human serum and interleukin 2 (IL-2), and activated by addition of the anti-CD3 antibody muromonab-CD3. At least 10% of the cells are NK cells (CD3-CD56+), but the substance also contains T cells (CD3+CD56-) and NK-like T cells (CD3+CD56+). At least 30% of the NK cells show cytotoxic activity and respond in a functional test against the leukemia cell line K562 with surface expression of lysosomal-associated membrane protein 1 (LAMP-1, CD107a).
The cells are cultured in medium supplemented with human serum and interleukin 2 (IL-2), and activated by addition of the anti-CD3 antibody muromonab-CD3. At least 10% of the cells are NK cells (CD3-CD56+), but the substance also contains T cells (CD3+CD56-) and NK-like T cells (CD3+CD56+). At least 30% of the NK cells show cytotoxic activity and respond in a functional test against the leukemia cell line K562 with surface expression of lysosomal-associated membrane protein 1 (LAMP-1, CD107a).
Иностранные названия
- Evencaleucelum (латинское)
- Evencaleucel (английское)
- Evencaleucel (немецкое)
- Évencaleucel (французское)
- Evencaleucel (испанское)
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