Эворпацепт

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

2484949-51-9

human signal-regulatory protein alpha (Sirp-α, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1) N-terminal fragment (1-119) variant (V>I⁶, A>I²⁷, I>F³¹, K>R⁵³, H>P⁵⁶, L>T⁶⁶, N>A⁸⁰) fused to a human immunoglobulin G1 C-terminal Fc fragment (120-345) (L>A¹³³, L>A¹³⁴, G>A¹³⁶, N>A¹⁹⁶, C-terminal K³⁴⁶ deleted), covalent disulfide bridged dimer, produced in Chinese hamster ovary (CHO) cells, glycoform alfa;
human signal-regulatory protein alpha (SIRPα, tyrosine-protein phosphatase non-receptor type substrate 1, inhibitory receptor SHPS-1) [V⁶>I, A²⁷>I, I³¹>F, K⁵³>R, H⁵⁶>P, L⁶⁶>T, N⁸⁰>A]-mutant, N-terminal (1-119)-fragment [binding domain for CD47 (inhibitor of phagocytosis by macrophages)], fused to a human immunoglobulin G1 C-terminal Fc fragment (CH2-CH3-CHS domains) [Homo sapiens IGHG1*03 (hinge (120-129, N-terminal hinge residues EPKSC deleted), CH2 L¹³³>A, L¹³⁴>A, G¹³⁶>A, N¹⁹⁶>A (130-239), CH3 (240-344), CHS K³⁴⁶>del (345))] (120-345), dimer (125-125':128-128')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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