Эврулейцел

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

allogeneic cytotoxic T lymphocytes (CTLs) specific for Epstein-Barr virus (EBV) latency proteins, including latent membrane protein 1 (LMP1), LMP2, and EBV nuclear antigen 1 (EBNA1). Peripheral blood mononuclear cells (PBMCs) isolated by apheresis from healthy EBV- seropositive donors are stored according to human leukocyte antigen (HLA) typing. The PBMCs are then co-cultured in media containing interleukin 2 (IL-2) together with irradiated antigen-presenting cells, created by incubation of PBMCs from the same donor with a replication- deficient adenovirus encoding a transgene that expresses a truncated EBNA1 protein fused to a polypeptide containing multiple epitopes from LMP1 and LMP2. The final cell population consists of >70% CD3+ T lymphocytes (mix of CD4+/CD8+ T lymphocytes), with the remaining cells made up of natural killer (NK) cells, B lymphocytes, and monocytes (typically <1%). The cells are specific for EBV protein antigens (LMP1, LMP2 and EBNA1) and lyse cells presenting epitopes from these EBV antigens in complex with a matching HLA

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