Эксидавнемаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2438229-02-6

immunoglobulin G4-kappa, anti-[Homo sapiens SNCA (synuclein alpha, PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4, synuclein alpha (non A4 component of amyloid precursor))], monoclonal antibody;
gamma4 heavy chain (1-444) [VH (Homo sapiens IGHV4-4*08 (79.4%) -(IGHD) -IGHJ3*01 (85.7%), CDR-IMGT [8.7.12] (26-33.51-57.96-107)) (1-118) -Homo sapiens IGHG4*01, G4v5 h P10 (CH1 (119-216), hinge 1-12 S10>P (226) (217-228), CH2 (229-338), CH3 (339-443), CHS K2>del (444)) (119-444)], (132-219')-disulfide with kappa light chain (1'-219') [V-KAPPA Musmus/Homsap (Mus musculus IGKV1-117*01 (89.0%) -IGKJ4*01 (91.7%) S120>Q (105)/Homo sapiens IGKV2-28*01 (85.0%) -IGKJ2*02 (100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (158), V101 (196) (113'-219')]; dimer (224-224'':227-227'')-bisdisulfide, produced in Chinese hamster ovary (CHO)-K1SV cell line lacking the glutamine synthetase gene (GS-KO), glycoform alfa

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