Экслинкибарт

Rec. INN (наименование, зарегистрированное ВОЗ)

2642171-64-8

immunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF9 (tumor necrosis factor receptor (TNFR) superfamily member 9, 4-1BB, T cell antigen ILA, CD137)], humanized monoclonal antibody;
gamma1 heavy chain humanized (1-444) [VH (Homo sapiens IGHV1-2*06 (88.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v47 CH2 G1.1del, G1v35 CH2 E29 (CH1 R120>K (213) (117-214), hinge 1-15 (215-229), CH2 G1.1>del, S29>E (265) (230-338), CH3 E12 (354), M14 (356) (339-443), CHS K2>del (444)) (117-444)], (219-214')-disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (85.3%) -IGKJ4*01 (90.9%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (225-225'': 228-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from CHO-K1 cell line, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

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