Фанастомиг

Rec. INN (наименование, зарегистрированное ВОЗ)

2761795-00-8

immunoglobulin L-kappa-H-gamma1_G1(VH-CH1-h)_L-kappa dimer, anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223) and anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody, bispecific;
[L-kappa-H-gamma1 heavy chain anti-LAG3 and anti-PDCD1 (1-665) [Lkappa anti-LAG3 (1-214) [V-KAPPA Musmus/Homsap (Mus musculus IGKV9-124*01 (88.4%) -IGKJ5*01 (91.7%) A120>Q (100)/Homo sapiens IGKV1-16*01 (84.2%) -IGKJ2*01 (90.9%) I126>L (106), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1-107) -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108-214)] -Hgamma1 heavy chain anti-PDCD1 (215-665) [VH (Homo sapiens IGHV3-48*02 (91.8%) -(IGHD) -IGHJ6*01 (92.9%), CDR-IMGT [8.8.14] (240-247.265-272.311-324)) (215-335) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, IGHG1v14 CH2 A1.3, A1.2 (CH1 R120>K (432) (336-433), hinge 1-15 (434-448), CH2 L1.3>A (452), L1.2>A (453) (449-558), CH3 E12 (574), M14 (576) (559-663), CHS (664-665)) (336-665)]]; (214-216')-disulfide with G1(VH-CH1-h light chain anti-LAG3 (1'-216') [VH Musmus/Homsap (Mus musculus IGHV14-4*01 (86.6%) -IGHD -IGHJ4*01 (92.3%) S123>T (108')/Homo sapiens IGHV1-69-2*01 (72.9%) -IGHD -IGHJ6*01 (87.5%), CDR-IMGT [8.8.6] (26'-33'.51'-58'.97'-102')) (1'-113') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120 (CH1 R120>K (210') (114'-211'), hinge 1-5 (212'-216')) (114'-216')]; (438-214''')-disulfide with L-kappa light chain Homo sapiens anti-PDCD1 (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-33*01 (86.3%) -IGKJ4*01 (100%), CDR-IMGT [6.3.9] (27'''-32'''.51'''-53'''.89'''-97''')) (1'''-107''') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (153'''), V101 (191''') (108'''-214''')]]; dimer (444-444'':447-447'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

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