Фазпилодемаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2517935-02-1

immunoglobulin G1-kappa, anti-[Homo sapiens KLB (klotho beta, b-Klotho)] and anti-[Homo sapiens FGFR1 (fibroblast growth factor receptor 1, FLT2, KAL2)], monoclonal antibody, bispecific;
gamma1 heavy chain anti-KLB (1-450) [VH (Homo sapiens IGHV3-66*01 (77.3%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.96-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v30 CH2 N84.4>G, G1v33 CH3 S22, A24, V86 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 N84.4>G (300) (234-343), CH3 E12 (359), M14 (361), T22>S (369), L24>A (371), Y86>V (410) (344-448), CHS (449-450)) (121-450)], (223-218')-disulfide with kappa light chain anti-KLB (1'-218') [V-KAPPA Musmus/Homsap (Mus musculus IGKV3-5*01 (81.8%) -IGKJ1*01 (83.3%) G120>Q (104), L124>V (108)/Homo sapiens IGKV4-1*01 (79.2%) -IGKJ1*01 (100%), CDR-IMGT [10.3.9] (27-36.54-56.93-101)) (1'-111') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (157), V101 (195) (112'-218')];
gamma1 heavy chain anti-FGFR1 (1''-446'') [VH (Homo sapiens IGHV3-66*01 (86.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1''-116'') -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, G1v30 CH2 N84.4>G, G1v32 CH3 W22 (CH1 R120>K (213) (117''-214''), hinge 1-15 (215''-229''), CH2 N84.4>G (296) (230''-339''), CH3 E12 (355), M14 (357), T22>W (365) (340''-444''), CHS (445''-446'')) (117''-446'')], (219''-214''')-disulfide with kappa light chain anti-FGFR1 (1'''-214''') [V-KAPPA (Homo sapiens IGKV1-39*01 (89.5%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'''-107''') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'''-214''')]; dimer (229-225'':232-228'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, non-glycosylated

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