Фицерафусп альфа

Prop. INN (наименование, предложенное ВОЗ)

USAN (наименование, принятое к употреблению в США)

2764727-44-6

chimeric immunoglobulin G1-kappa anti-(human epidermal growth factor receptor) fused at the C-terminus of both light chains, via a (G4S)3 peptide linker, to a fragment of the extracellular domain of human TGF-beta receptor type-2 (TGFR-2, TGF-beta type II receptor, transforming growth factor-beta receptor type II), glycoform alfa;
gamma 1 heavy chain (1-448) [VH (Mus musculus IGHV2-2*03 -(IGHD) -IGHJ3*01, CDR-Kabat [5.16.11] (31-35.50-65.98-108)) (1-119) -Homo sapiens IGHG1*08 (CH1 (120-217), hinge (218-232), CH2 (233-342), CH3 (343-447), CHS K449>del (448)) (120- 448)], (222-214')-disulfide with kappa light chain (1'- 214') [V-KAPPA (Mus musculus IGKV5-48*01 - IGKJ5*01, CDR-Kabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')] fused via a (G4S)3 peptide linker (215'-229') to human TGF- beta receptor type-2 (TGFR-2, TGF-beta type II receptor, transforming growth factor-beta receptor type II) extracellular domain fragment 23-159 (230-366 in the current sequence); dimer (228-228'', 231-231'')- bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa

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