Фиролимоген аутотемцел
Firolimogene autotemcelМНН
Rec. INN (наименование, зарегистрированное ВОЗ)
Химическое название
autologous CD34+ cells isolated from bone marrow of newly diagnosed X-linked severe combined immunodeficiency (X-SCID) patients, transduced ex vivo with a self-inactivating lentiviral vector, encoding codon-optimized human interleukin-2 receptor subunit gamma (IL2RG) also known as common gamma chain (γc), driven by a short version of the EF1α promoter.
The vector contains human immunodeficiency virus (HIV) central polypurine tract sequences, the HIV Rev response element (RRE) and is flanked by HIV long terminal repeats. The vector also contains a 400bp insulator fragment from the chicken beta-globin locus inserted into the deleted U3 region of the HIV long terminal repeat followed by a polyadenylation sequence derived from the rabbit beta-globin gene.
The vector contains human immunodeficiency virus (HIV) central polypurine tract sequences, the HIV Rev response element (RRE) and is flanked by HIV long terminal repeats. The vector also contains a 400bp insulator fragment from the chicken beta-globin locus inserted into the deleted U3 region of the HIV long terminal repeat followed by a polyadenylation sequence derived from the rabbit beta-globin gene.
Структура
Иностранные названия
- Firolimogenum autotemcelum (латинское)
- Firolimogene autotemcel (английское)
- Firolimogen autotemcel (немецкое)
- Firolimogène autotemcel (французское)
- Firolimogén autotemcel (испанское)
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