Флотетузумаб

Rec. INN (наименование, зарегистрированное ВОЗ)

USAN (наименование, принятое к употреблению в США)

DB15223

1664355-28-5

immunoglobulin scFv_scFv, anti-[Homo sapiens IL3RA (interleukin 3 receptor subunit alpha, interleukin 3 receptor alpha (low affinity), CD123)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)]; Mus musculus and humanized monoclonal antibody scFv_scFv, bispecific;
scFv-lambda-heavy-E-coil (1-272) [V-LAMBDA anti-CD3E (Mus musculus IGLV1-01 (81.2%) -IGLJ1*01 (100%)/Homo sapiens IGLV7-46 (77.9%) -IGHJ3*02 (100%)) [9.3.9] (1-109) -9-mer tetraglycyl-seryl-tetraglycyl linker (110-118) -humanized VH anti-IL3RA (Homo sapiens IGHV1-46*01 (83.7%) -(IGHD) -IGHJ6*01 (90.9%)) [8.8.13] (119-238) -6-mer diglycyl-cysteinyl-triglycyl linker (239-244) -E-coil motif (245-272)], (241-249')-disulfide with scFv-kappa-heavy-K-coil (1'-280') [V-KAPPA anti-IL3RA (Mus musculus IGKV8-19*01 (91.1%) -IGKJ2*01 (91.7%)/Homo sapiens IGKV4-1*01 (88.1%) -IGKJ2*01 (100%)) [12.3.9] (1'-113') -8-mer triglycyl-seryl-tetraglycyl linker (114'-121') -VH anti-CD3E (Mus musculus IGHV10-1*02 (89.9%) -(IGHD) -IGHJ3*01 (93.9%)/Homo sapiens IGHV3-72*01 (87.0%) -(IGHD) -IGHJ6*01 (90.9%)) [8.10.16] (122'-246')] -6-mer diglycyl-cysteinyl-triglycyl linker (247'-252') -K-coil motif (253'-280')]

C₂₆₁₈H₄₀₄₀N₇₀₄O_813S16

58898,19 г/моль

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