Фрексалимаб

Rec. INN (наименование, зарегистрированное ВОЗ)

2515463-86-0

immunoglobulin G1-kappa, anti-[Homo sapiens CD40LG (CD40 ligand, CD40L, tumor necrosis factor ligand superfamily member 5, TNFSF5, tumor necrosis factor related activation protein, TRAP, CD154)], monoclonal antibody;
gamma1 heavy chain (1-450) [VH Musmus/Homsap (Mus musculus IGHV3-8*02 (82.3%) -(IGHD) -IGHJ2*01 (100%)/Homo sapiens IGHV4-59*11 (81.2%) -(IGHD) -IGHJ4*01 (86.7%) L123>T (115), V124>L (116), CDR-IMGT [8.7.14] (26-33.51-57.96-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1, G1v20 CH2 A105 (CH1 K120 (217) (121-218), hinge 1-15 (219-233), CH2 E31>R (272), K105>A (325) (234-343), CH3 D12 (359), L14 (361) (344-448), CHS (449-450)) (121-450)], (223-214')-disulfide with kappa light chain (1'-214') [V-KAPPA Musmus/Homsap (Mus musculus IGKV6-13*01 (83.2%) -IGKJ2*01 (100%)/Homo sapiens IGKV1-33*01 (76.8%) -IGKJ2*01 (91.7%) Q120>G (100), CDR-IMGT [6.3.9] (27-32.50-52.89-97)) (1'-107') -Homo sapiens IGKC*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-DXB11, glycoform alfa

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